Pd-Catalyzed Dynamic Kinetic Enantioselective Arylation of Silylphosphines

Abstract

Palladium-catalyzed cross-couplings represent a powerful method for the formation of new bonds. A catalytic, enantioselective P−C bond-forming reaction proceeding via a Pd-mediated arylation of silylphosphines was developed for the synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can be made with a variety of functionalized aryl iodides; however, they proceed most enantioselectively with 2-iodo- N, N -diisopropylbenzamides.