Reduced Biocide Susceptibility in <i>Candida albicans</i> Biofilms

Jeniel E. Nett, Kristie M. Guite, Alex Ringeisen, Kathleen A. Holoyda, David R. Andes

Antimicrobial Agents and Chemotherapy · 2008 · 70 citations · 32 references

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Abstract

Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H(2)O(2), and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H(2)O(2)) and fluconazole demonstrated that the combination had enhanced efficacy.

References

32