Clinical Orthopaedics and Related Research · 1976 · 12 citations · 0 references
MedicineEndocrinologyBone MetabolismCalcium HomeostasisMineral MetabolismBone Metabolism DisordersBone MineralizationMetabolic Bone DiseasePhosphate HomeostasisVitamin DVitamin D MetabolismBone Mineral DiseaseCalcificationCalcium Deficiency In ChildrenPediatric Bone DiseasePediatric Vitamin D DeficiencyVitamin D Effects On BoneVitamin D InsufficiencyVitamin Replacement Therapy
Two severely osteopenic adolescent males with clinical manifestations of adult onset hypophosphatemic osteomalacia were resistant respectively to physiological and pharmacological doses of vitamin D. Clinical improvement ensued following initiation of pharmacological doses of vitamin D and phosphate. Non-decalcified bone biopsies obtained before and during therapy exhibited correction of an isolated mineralization in the second. The response to treatment was reflected in striking changes in tetracycline-labelled calcification fronts in both patients.