Publication | Closed Access
Pyrazinamide: A Frontline Drug Used for Tuberculosis. Molecular Mechanism of Action Resolved after 50 Years?
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Citations
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References
2012
Year
Pharmaceutical ScienceFrontline DrugPharmacotherapyAntimicrobial ChemotherapyMolecular ModePharmaceutical ChemistryDrug ResistanceMolecular PharmacologyMedicinal ChemistryMycobacterium TuberculosisPulmonary TuberculosisBiochemistryMolecular MechanismTuberculosisDrug DevelopmentPharmacologyImportant Tb DrugAction ResolvedNatural SciencesMedicineDrug Discovery
Target acquired! After 50 years of use, has the molecular mode of action finally been identified for pyrazinamide? Recently, inhibition of trans-translation in Mycobacterium tuberculosis was suggested as a novel mode of action for this important TB drug. The results of the study by Zhang et al., reported in Science, are highlighted here.
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