A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

Nomenclature for human CYP2D6 alleles

Ann K. Daly, Jürgen Brockmöller, Franck Broly et al. · Pharmacogenetics · 1996 · 400 citations

Life Sciences, Genetics, Molecular Genetics +13

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

Shigeru Yamano, Jun Tatsuno, Frank J. Gonzalez · Biochemistry · 1990 · 384 citations

Medicine, Biochemistry, Pharmacology +8

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

Pedro M. Fernández‐Salguero, Susan M.G. Hoffman, S. Cholerton et al. · PubMed · 1995 · 296 citations · Full text

Medicine, Genetics, Pharmacology +12

CYTOTOXIC CHEMOTHERAPY FOR ADVANCED RENAL CELL CARCINOMA

Alan Yagoda, Daniel P. Petrylak, Seth Thompson · Urologic Clinics of North America · 1993 · 208 citations

Medicine, Oncology, Pharmacology +10

Interindividual variability of coumarin 7-hydroxylation in healthy volunteers

Arja Rautio, H Kraul, Anneli Kojo et al. · Pharmacogenetics · 1992 · 163 citations

Pharmacy, Pharmacokinetics, Pharmacology +13