New Sesquiterpene Lactones of Eremophilane-Type from <i>Ligularia Fauriei</i> (F<scp>r</scp>.) Koidz.

Abstract

Abstract Two new sesquiterpene lactones of eremophilane-type were isolated from Ligularia Fauriei (Fr.) Koidz., and their structures including absolute stereochemistry were shown to be 8β-hydroxyeremophil-7(11)-ene-12,8α;14β,6α-diolide (1) and eremophil-7(11)-ene-12,8α;14β,6α-diolide (2), respectively. The isolation of the two known lactones, 6β,8β-dihydroxyeremophil-7(11)-en-12,8α-olide (3) and 6β-hydroxyeremophil-7(11)-en-12,8α-olide (4), is also described. The photosensitized autoxidation of the known furanoeremophilan-14β,6α-olide (5) gave 1 and 8β-methoxyeremophil-7(11)-ene-12,8α;14β,6α-diolide (18).