Human growth hormone in cultures of human pituitary tumors

Abstract

✓ Tissue culture medium of 14 human pituitary adenomas removed from acromegalic and hypopituitary patients was analyzed for human growth hormone (HGH). High HGH levels were detected in the culture medium of all adenomas removed from acromegalic patients. HGH was undetectable in the tissue culture medium of six of eight adenomas removed from hypopituitary patients. Elevated HGH levels were also found in the culture medium of pituitary tissue obtained from a juvenile diabetic patient.