Concepedia

Palladium-Catalyzed Decarboxylative Benzylation of Diphenylglycinate Imines

Wendy H. Fields, Jason J. Chruma

Organic Letters · 2009 · 80 citations · 36 references

DOI

Concepts

Abstract

General reaction conditions for the Pd-catalyzed decarboxylative benzylation of benzyl diphenylglycinate imines are described. The overall procedure requires a simple catalyst/ligand combination to form a new Csp(3)-Csp(3) bond. Microwave irradiation greatly accelerated the transformation. Moreover, various heteroaromatic moieties are tolerated in both the imine and ester components.

References

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A Highly Active Palladium Catalyst for Intermolecular Hydroamination. Factors that Control Reactivity and Additions of Functionalized Anilines to Dienes and Vinylarenes

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The Copper‐Catalyzed Decarboxylative Coupling of the sp<sup>3</sup>‐Hybridized Carbon Atoms of α‐Amino Acids

Hai‐Peng Bi, Liang Zhao, Yong‐Min Liang et al. · Angewandte Chemie International Edition · 2009 · 302 citations · Full text

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Catalytic Asymmetric Hiyama Cross-Couplings of Racemic α-Bromo Esters

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