Anoxia-Induced NF-kB-Dependent Upregulation of NCX1 Contributes to Ca ²⁺ Refilling Into Endoplasmic Reticulum in Cortical Neurons

Abstract

These results suggest that nuclear factor kappa B-dependent NCX1 upregulation may play a fundamental role in Ca(2+) refilling in the endoplasmic reticulum, thus helping neurons to prevent endoplasmic reticulum stress during oxygen and glucose deprivation.