Regio- and stereo-selective desulphurizative γ-substitution of α-substituted β-methylallyl sulphoxides and sulphones with lithium dialkylcuprates providing trisubstituted olefins

Abstract

α-Substituted β-methylallyl sulphoxides (2) and sulphones (3) undergo regio- and stereo-selective desulphurizative γ-substitution by the action of lithium dialkylcuprates in ether. The reaction provides a new method for the synthesis of trisubstituted E-olefins E-(4).