Biosilicate® — A multipurpose, highly bioactive glass-ceramic. In vitro, in vivo and clinical trials

TLDR

Biosilicate® is a highly bioactive, osteoconductive, osteoinductive, non‑cytotoxic, non‑genotoxic, antibacterial glass‑ceramic that is strong and tough in monolithic form, matches the in‑vitro bioactivity of Bioglass 45S5, and can be fabricated as powder, monolithic, or 3D scaffold for surgical use. The review critically analyzes 28 theses, dissertations, and over 30 scientific papers on Biosilicate® across diverse applications over the past 20 years. Biosilicate® proved to be a versatile, multipurpose biomaterial, successfully tested in numerous in‑vitro, in‑vivo, and clinical studies, and is a promising option for a wide range of tissue‑engineering applications, with several trials ongoing.

Abstract

In this review we critically analyze 28 theses and dissertations and over 30 scientific papers that tested Biosilicate®, a highly bioactive glass-ceramic, in a number of applications throughout the past 20 years. Biosilicate® presents a combination of positive features for bone tissue regeneration: it is highly bioactive, osteoconductive, osteoinductive, non-cytotoxic, non-genotoxic and has antibacterial properties. In addition, in the monolithic form, it is quite strong and tough. Its in vitro bioactivity is similar to that of the gold standard Bioglass 45S5. Biosilicate® has shown to be a very versatile, multipurpose biomaterial. It can be applied in powder, monolithic and 3D scaffold forms that could be easily machined during surgical procedures. This material has been successfully tested in a number of in vitro, in vivo and clinical studies, and several trials are ongoing. Biosilicate® is indeed a great option for a wide range of tissue engineering applications.