<i>ortho</i>-Disubstituted <i>F</i>-Benzenes. II. One-pot Syntheses of (<i>F</i>-Benzo)heterocyclic Compounds

Abstract

Abstract Convenient one-pot methods of converting F-benzene into substituted (F-benzo)furans, (F-benz)oxazole, -imidazolines, and -thiazoline are described. Ambident nucleophiles are generated in situ from ketone, amide, urea, thiourea, and their derivatives in the presence of sodium hydride. Enolate-anion nucleophiles are also generated in situ from silyl enol ethers in the presence of potassium fluoride in anhydrous DMF.