Publication | Closed Access
Estimation of Haplotype Frequency and Linkage Disequilibrium Parameter in the HLA System<sup>1</sup>
20
Citations
18
References
1978
Year
Linkage DisequilibriumConventional FormulaeUnrelated IndividualsGenotype-phenotype AssociationMolecular EcologyHaplotype FrequencyMedicineGeneticsHaplotype DeterminationLinkage AnalysisStatistical GeneticsBiostatisticsGenetic VariationHla TypingPublic HealthPopulation GeneticsStatisticsLinkage Disequilibrium Parameter
Conventional formulae currently employed were extended to calculate the haplotype frequency and the corresponding variance for an arbitrary number (n) of loci when unrelated individuals were investigated. A formula is presented for the variance for the degree of three locus linkage disequilibrium.
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