Archiv der Pharmazie · 2001 · 35 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyChemotherapyDrug DiscoveryPolymer ChemistryAmino Acid ProdrugsCarrier-linked ProdrugsPulmonary TuberculosisTuberculosis PharmacotherapyChemotherapeutic Prodrug DesignMinimal Effective ConcentrationMycobacterium Tuberculosis InfectionPolymeric ProdrugsPolymers In Drug FormulationTuberculosis ChemoprophylaxisTuberculosis Drug DevelopmentTuberculosis Drug Resistance
With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.