DISEASES OF THE LIVER

Abstract

In a previous paper we have reported the effect of experimental obstructive jaundice on hepatic function as measured by certain tests. 1 At that time particular attention was paid to the changes in the fructose tolerance, the nitrogen partition in the blood, the serum bilirubin and the phenoltetrachlorphthalein test. 2 We now wish to report further studies with particular reference to the bromsulphalein test of Rosenthal and White, 3 the bile acid content of the blood and the elimination of intravenously injected bile acids. The serum bilirubin was followed as an index to the degree of jaundice, a standard of reference being thus furnished for the comparison of the results in the two series of experiments. Two groups comprising a total of fifteen animals were studied: those in which the common duct had been ligated, and those in which cholecystectomy had been performed in addition to ligation of the common duct. In all