Long-Term Management of Generalized Pustular Psoriasis with Infliximab: Case Series

Abstract

BACKGROUND: Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports. OBJECTIVE: The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab. METHODS: Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab. RESULTS: Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate. CONCLUSION: Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.