Twenty Years of Naproxen Technology

Abstract

This review includes (1) a discussion of marketing and manufacturing of optically pure pharmaceuticals including naproxen, (2) an historical overview of Syntex naproxen manufacturing technology, (3) a comparison of classical resolution and asymmetric technologies specific to naproxen manufacture, (4) a cost comparison of naproxen starting materials, (5) data on the Syntex resolution technology and the impact of continuous process research and development on that technology, and (6) some environmental aspects of naproxen manufacturing.