Experimental Biology and Medicine · 1958 · 33 citations · 0 references
Life SciencesEndocrinologyPhysiologyHormone BiochemistryNeuroendocrinologyReproductive EndocrinologyAdrenal EndocrinologyAdrenal HormonesHypothalamic-pituitary AxisHypothalamic-pituitary RegulationNeuroendocrine PhysiologyPituitary HormonesAdrenal SuppressionAscorbic Acid PhysiologyHypothalamic-pituitary-adrenal Axis SuppressionPituitary Hormone HypersecretionPituitary HypersecretionPituitary HyposecretionPituitary PhysiologyPituitary-adrenal Interaction
Pitressin depletes adrenal ascorbic acid and potentiates the action of ACTH in the 24-hour hypophysectomized rat. The observation that Pitressin depletes adrenal ascorbic acid in the rat with a lesion in the median eminence has been confirmed. Only part of this effect can be explained by release of ACTH from the pituitary since Pitressin will also deplete adrenal ascorbic acid in a lesioned rat which has been decapitated.