Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

Chang-jie Chen, Janice E. Chin, Kazumitsu Ueda et al. · Cell · 1986 · 1.9K citations

Life Sciences, Genetics, Molecular Biology +14

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

Andrew K. Godwin, A Meister, P J O'Dwyer et al. · Proceedings of the National Academy of Sciences · 1992 · 928 citations

Medicine, Cancer Biology, Oncology +15

Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.

Toshihisa Ishikawa, Francis Ali‐Osman · Journal of Biological Chemistry · 1993 · 538 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Coordinated Induction of / Pump and γ-Glutamylcysteine Synthetase by Heavy Metals in Human Leukemia Cells

Toshihisa Ishikawa, Jiaju Bao, Y Yamane et al. · Journal of Biological Chemistry · 1996 · 267 citations · Full text

Medicine, Cancer Biology, Molecular Biology +14

Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

Pier Luigi Tazzari, A Cappellini, Francesca Ricci et al. · Leukemia · 2007 · 199 citations

Life Sciences, Molecular Biology, Oncology +17