Lymphocyte migration through the blood–brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre‐existence of virus and tumour necrosis factor (TNF)‐α within the central nervous system (CNS): studies using an <i>in vitro</i> feline BBB model

Abstract

Small quantities of virus in the brain together with TNF-alpha have the potential to stimulate greater cell and viral entry into the CNS and this is likely to involve important factors other than further TNF-alpha production. Lymphotropic lentivirus entry to the CNS is governed by many factors similar to macrophage-tropic strains.