Association between renin–angiotensin system gene polymorphism and essential hypertension: a community-based study

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

Brigitte Rigat, C. Hübert, F Alhenc‐Gelas et al. · Journal of Clinical Investigation · 1990 · 3.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Molecular basis of human hypertension: Role of angiotensinogen

Xavier Jeunemaı̂tre, Florent Soubrier, Yuri Kotelevtsev et al. · Cell · 1992 · 1.9K citations

Life Sciences, Molecular Biology, Physiology +14

Evidence for Association and Genetic Linkage of the Angiotensin-Converting Enzyme Locus With Hypertension and Blood Pressure in Men but Not Women in the Framingham Heart Study

Christopher J. O’Donnell, Klaus Lindpaintner, Martin G. Larson et al. · Circulation · 1998 · 555 citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Angiotensinogen Genotype, Sodium Reduction, Weight Loss, and Prevention of Hypertension

Steven C. Hunt, Nancy R. Cook, Albert Oberman et al. · Hypertension · 1998 · 171 citations · Full text

Medicine, Genetics, Molecular Genetics +17

Essential Hypertension and 5′ Upstream Core Promoter Region of Human Angiotensinogen Gene

Tomoaki Ishigami, Satoshi Umemura, Kouichi Tamura et al. · Hypertension · 1997 · 100 citations

Medicine, Genetics, Molecular Genetics +15