Journal of Clinical Pathology · 2000 · 193 citations · 2 references
MedicineEndocrinologyOncologyBreast OncologyEndocrine OncologySteroid BiochemistryBiomarkers In PathologyCancer BiomarkersEndocrine TestingHormone ReceptorsImmunohistochemistryTumor MarkersAssayImmunohistochemical BiomarkersImmunohistochemical DetectionImmunohistochemical MarkersImmunohistochemical StainingPositive Predictive ValueReceptorsSteroid Hormone Assays
The biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value. This paper reports both a practical protocol and a scoring system that should achieve this aim. This approach should be applicable to many more biomarkers detected by immunohistochemistry.
2
Tamoxifen for early breast cancer: an overview of the randomised trials
The Lancet · 1998 · 4.1K citations
Jennet Harvey, Gary M. Clark, C. Kent Osborne et al. · Journal of Clinical Oncology · 1999 · 2.1K citations
Medicine, Endocrinology, Oncology +17