Conformational analysis of cycloartenol, 24-methylenecycloartanol and their derivatives.

Abstract

A conformational analysis of cycloartenol, 24-methylenecycloartanol and their derivatives was carried out in the solution and the solid state by an NMR study and X-ray crystallographic analysis, respectively. Complete assignments of the 1H NMR spectra of these compounds were made in order to elucidate the conformation involving the ring system and side chain. Rings A to C had a chairhalfchair-boat conformation, and the side chain had a zig-zag conformation.