C-Reactive Protein Upregulates Angiotensin Type 1 Receptors in Vascular Smooth Muscle

Abstract

CRP, at concentrations known to predict cardiovascular events, upregulates AT1-R-mediated atherosclerotic events in vascular smooth muscle in vitro and in vivo. These data lend credence to the notion that CRP functions as a proatherosclerotic factor as well as a powerful risk marker.