Transcapillary Passage of Plasma Proteins in Experimental Burns

Abstract

Abstract The “leakage” of proteins from plasma to interstitial fluid in burns was studied experimentally in dogs. The concentration of orosomucoid, α 1 ‐antitrypsin, albumin, haptoglobin, IgG, β 1 C‐globulin and α 2 ‐macroglobulin were determined in plasma and in lymph from the leg before and after scalding of the paw. The lymph/plasma ratio of all proteins except that of α 2 ‐macroglobulin increased after scalding, indicating an increased capillary permeability to proteins with molecular weights up to 300,000.