Rh(I)-Catalyzed Direct <i>o</i><i>rtho</i>-Alkenylation of Aromatic Ketimines with Alkynes and Its Application to the Synthesis of Isoquinoline Derivatives

Abstract

[reaction: see text] Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.