Applied Physics B · 2014 · 103 citations · 48 references
MedicineNuclear EngineeringRadiation OncologyRadiation DosimetryRadiation PhysicsRadiation TransportAccelerator PhysicsExternal Beam RadiotherapyParticle TherapyProton DosimetryProton TherapyRadiation TherapyBeam Delivery SystemsDepth Dose DistributionEnergy-efficient TransportLaser-driven Ion AccelerationParticle Acceleration
The recent advancements in the field of laser-driven particle acceleration have made Laser-driven Ion Beam Therapy (L-IBT) an attractive alternative to the conventional particle therapy facilities. To bring this emerging technology to clinical application, we introduce the broad energy assorted depth dose deposition model which makes efficient use of the large energy spread and high dose-per-pulse of Laser Accelerated Protons (LAP) and is capable of delivering homogeneous doses to tumors. Furthermore, as a key component of L-IBT solution, we present a compact iso-centric gantry design with 360° rotation capability and an integrated shot-to-shot energy selection system for efficient transport of LAP with large energy spread to the patient. We show that gantry size could be reduced by a factor of 2–3 compared to conventional gantry systems by utilizing pulsed air-core magnets.
48
Intense High-Energy Proton Beams from Petawatt-Laser Irradiation of Solids
R. A. Snavely, M. H. Key, S. P. Hatchett et al. · Physical Review Letters · 2000 · 1.7K citations
Radiological Use of Fast Protons
Robert R. Wilson · Radiology · 1946 · 1.4K citations
Natural Sciences, Physics, Radiology +14
Highly Efficient Relativistic-Ion Generation in the Laser-Piston Regime
T. Zh. Esirkepov, M. Borghesi, S. V. Bulanov et al. · Physical Review Letters · 2004 · 1K citations · Full text
Laser-driven proton scaling laws and new paths towards energy increase
J. Fuchs, P. Antici, E. d’Humières et al. · Nature Physics · 2005 · 772 citations