Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial <i>β</i> ‐cell protection in individuals with type 2 diabetes

Abstract

Adding basal insulin to metformin reduces postprandial beta-cell load. While GLA and NPH had comparable effects at breakfast, GLA reduces beta-cell stress more effectively at dinner, and with a trend at lunch, most probably because of its longer lasting pharmacodynamic profile.