FEBS Letters · 1993 · 77 citations · 14 references
Life SciencesBiochemistryCell BiologyCell SignalingEnzymologySignal TransductionCalcium SignalingCalcium-binding ProteinsIntracellular Calcium SignalingRetinal NeurobiologyCalcium Signaling In PhotoreceptorsCalcium-binding Proteins In PhototransductionProtein-protein AssociationRetinal Photoreceptor PhysiologyRetinal PhysiologyRhodopsin Function
A protein with apparent M(r) 26 kDa (p26 [(1991) Biokimya 56, 225-228] or recoverin [(1991) Science 251, 915-918]) was suggested to activate GC in a calcium dependent manner in bovine retina rod cells [(1991) Science 251, 915-918; (1991) EMBO J, 10, 793-798]. However, according to our present data homogeneous p26 preparations do not activate the enzyme. At the same time we have revealed a complex of p26 with an unidentified protein, presumably RK, in bovine ROS. Calcium favours formation of the complex whereas EGTA addition (which corresponds to a low free Ca2+ concentration) leads to its dissociation.
14
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
Ulrich K. Laemmli · Nature · 1970 · 251.6K citations
Recoverin: a Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase
Alexander M. Dizhoor, Sanghamitra Ray, Santosh Kumar et al. · Science · 1991 · 571 citations