THE MISMATCH REPAIR GENE hMSH2 IS MUTATED IN THE PROSTATE CANCER CELL LINE LNCaP

Abstract

The well described prostate cancer cell line LNCaP has a mutation in the hMSH2 gene, resulting in loss of expression and possible evidence of microsatellite instability. To our knowledge our finding is the first demonstration of a genetic alteration in hMSH2 in a prostate cancer cell line.