Antidiuretic Action of Chlorpropamide in Idiopathic Diabetes Insipidus

Abstract

Chlorpropamide was given to 3 patients with idiopathic diabetes insipidus and 2 with nephrogenic diabetes insipidus. Its influence on urine flow, “free” water and osmolal clearances as well as on blood sugar was studied. A sharp antidiuretic response was observed in the first 3 patients. Although the antidiuretic mechanism of chlorpropamide is not yet known, there is a strong suggestion that it acts in a way similar to that of the antidiuretic hormone, at least in some respects. The possibility of the use of chlorpropamide in the treatment of idiopathic diabetes insipidus is suggested.