Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +15

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

Keiji Imoto, Christopher Büsch, Bert Sakmann et al. · Nature · 1988 · 792 citations

Life Sciences, Biochemistry, Biophysics +14

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

U. Benjamin Kaupp, Tetsuhiro Niidome, Tsutomu Tanabe et al. · Nature · 1989 · 670 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons

R S Dhallan, King‐Wai Yau, Karen Schrader et al. · Nature · 1990 · 653 citations

Life Sciences, Neurobiology, Neuroscience +17