Aprotinin reduces intraoperative and postoperative blood loss in membrane oxygenator cardiopulmonary bypass

The Standardized Normal Ivy Bleeding Time and Its Prolongation by Aspirin

C. Harold Mielke, Marc Kaneshiro, Ian A. Maher et al. · Blood · 1969 · 663 citations · Full text

Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release.

Laurence A. Harker, Thomas W. Malpass, Herman Branson et al. · PubMed · 1980 · 663 citations

Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol)

Benjamin P. Bidstrup, David Royston, Ralph N. Sapsford et al. · Journal of Thoracic and Cardiovascular Surgery · 1989 · 539 citations

Cardiac Anaesthesia, Cardiovascular Disease, Medicine +10

Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs.

Hans Fritz, G Wunderer · PubMed · 1983 · 420 citations

Pharmaceutical Science, Bioorganic Chemistry, Antiparasitic Agent +17

Aprotinin protects platelets against the initial effect of cardiopulmonary bypass

Willem van Oeveren, Marcel P. Harder, K. J. Roozendaal et al. · Journal of Thoracic and Cardiovascular Surgery · 1990 · 374 citations

Thrombosis, Cardiovascular Disease, Blood Platelet +9