Persistent effect of early, brief angiotensin-converting enzyme inhibition on segmental pressure dependency of aortic stiffness in spontaneously hypertensive rats

Abstract

Early but not late brief ACEi decreased arterial pressure and isobaric wall stiffness in SHR. This was associated with marked alteration of wall structure and the effects persisted after cessation of early treatment. The structural mechanisms responsible for this change varied segmentally along the aortic trunk.