Epidermal Inactivation of the Glucocorticoid Receptor Triggers Skin Barrier Defects and Cutaneous Inflammation

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

François Tronche, Christoph Kellendonk, Oliver Kretz et al. · Nature Genetics · 1999 · 1.9K citations

Life Sciences, Neurobiology, Neuroscience +16

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

Xiao-ding Peng, Pei-Zhang Xu, Mei-Ling Chen et al. · Genes & Development · 2003 · 826 citations · Full text

Medicine, Developmental Biology, Genetics +17

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

Rafael de Cid, Eva Riveira‐Muñoz, Patrick L.J.M. Zeeuwen et al. · Nature Genetics · 2009 · 538 citations · Full text

Medicine, Genetics, Molecular Genetics +11

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis

Mei Li, Pierre Hener, Zhikun Zhang et al. · Proceedings of the National Academy of Sciences · 2006 · 531 citations · Full text

Medicine, Dermatology, Pharmacology +17

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

Milan Surjit, Krishna Priya Ganti, Atish Mukherji et al. · Cell · 2011 · 525 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +12