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Mutation of <i>Pseudomonas aeruginosa</i> to piperadillin resistance mediated by β-lactamase production
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1985
Year
GeneticsBacteriologyMolecular BiologyAntibiotic ResistanceBacterial PathogensDrug ResistanceProlonged StorageInfection ControlAntimicrobial ResistanceHealth SciencesAntimicrobial Drug DiscoveryPseudomonas Aeruginosaβ-Lactamase ProductionMolecular MicrobiologyBacterial ResistanceClinical MicrobiologyAntimicrobial Resistance GeneAntimicrobial SusceptibilityAntibioticsMicrobiologyPiperacillin-resistant MutantsMedicineMicrobial Genetics
Piperacillin-resistant mutants were detected in each of ten strains of Pseudomonas aeruginosa. The resistance was associated with constitutive production by the strains of high levels of beta-lactamase which was similar in character to the induced chromosomal Id beta-lactamase of the parent strains. This type of mutation to piperacillin-resistance occurred at a low frequency. The beta-lactamase production and piperacillin-resistance were stable on repeated subculture and prolonged storage of the strains.