Improved Recovery following Posttransplant Acute Renal Failure in Rat Renal Isografts with an Oral Endothelin-A Receptor Antagonist

Abstract

Treatment with the selective ET-A receptor antagonist LU135252 accelerates recovery of renal function after isogeneic renal transplantation and attenuates cellular graft infiltration. This effect could have major implications for the treatment of patients undergoing renal transplantation, as an improved initial renal function may delay the onset of chronic allograft rejection.