Enantioselective Synthesis of <scp>D</scp>‐<i>threo</i>‐β‐Hydroxy‐α‐amino Acids with Titanium‐Carbohydrate Complexes

Abstract

The addition of the glycine enolate to aldehydes to give the title compounds 2 proceeds with high enantioselectivity and diastereoselectivity, when the titanate 1 is used as chiral template and reagent (R*, see the two preceding communications). Amino acid esters with free or protected amino groups are readily accessible.