Journal of the American Chemical Society · 2008 · 320 citations · 7 references
EngineeringBiomedical EngineeringOncologyBiomedical OpticsBiosensorsMolecular DiagnosticsCancer DetectionCirculating Tumor CellsOptical BiosensingOptical BiosensorsRaman SpectroscopyTumor MarkersCirculating Tumor BiomarkersCirculating Tumor Cell BiomarkersCirculating Tumor MarkersDirect EnumerationPeripheral EnumerationSurface-enhanced Raman ScatteringSurface-enhanced Raman Scattering BiosensingSurface-enhanced Raman Scattering Biosensors
A novel, homogeneous SERS-based cell detection assay was developed for rapid and direct enumeration of circulating tumor cells in the presence of whole blood. Magnetic beads and SERS tags were respectively conjugated to EpCAM and her2 antibodies for the capture and detection of approximately 50 tumor cells/mL in the presence of whole blood in less than 1 h.
7
Composite Organic−Inorganic Nanoparticles as Raman Labels for Tissue Analysis
Lei Sun, Kung‐Bin Sung, Claire Dentinger et al. · Nano Letters · 2007 · 145 citations