κ-Opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice

A psychomotor stimulant theory of addiction.

Roy A. Wise, Michael A. Bozarth · Psychological Review · 1987 · 2.7K citations

Medicine, Neuroscience, Pharmacology +17

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

Rainer Spanagel, A. Herz, Toni S. Shippenberg · Proceedings of the National Academy of Sciences · 1992 · 1K citations

Life Sciences, Neuroscience, Pharmacology +16

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

G. Di Chiara, Assunta Impérato · Journal of Pharmacology and Experimental Therapeutics · 1988 · 922 citations

Medicine, Neuroscience, Pharmacology +17

The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study

Rainer Spanagel, Albert Herz, Toni S. Shippenberg · Journal of Neurochemistry · 1990 · 541 citations

Medicine, Neuroscience, Pharmacology +17

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

R. Bals-Kubik, A. Ableitner, A. Herz et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 528 citations

Medicine, Neuroscience, Pharmacology +17