Beta₂‐glycoprotein I binds thrombin via exosite I and exosite II: Anti–β₂‐glycoprotein I antibodies potentiate the inhibitory effect of β₂‐glycoprotein I on thrombin‐mediated factor XIa generation

Abstract

We demonstrate that beta(2)GPI interacts with thrombin exosites I and II. This novel finding necessitates a reinterpretation of previous studies from which the detection of anti-human thrombin antibodies in APS has been reported. We also show that anti-beta(2)GPI antibodies potentiate the inhibitory effect of beta(2)GPI on thrombin-mediated factor XIa generation.