Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in Gs protein activation

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

Protein Chemistry, Protein Function, Protein Assembly +5

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

André DeLÉAN, Peter J. Munson, David Rodbard · American Journal of Physiology-Endocrinology and Metabolism · 1978 · 2.4K citations

Sigmoidal Dose-response Curves, Physiologically-based Pharmacokinetic Modeling, Bioanalysis +21

The probable arrangement of the helices in G protein-coupled receptors.

J.M. Baldwin · The EMBO Journal · 1993 · 978 citations · Full text

Probable Arrangement, Signal Transduction, Molecular Physiology +8

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

Michael A. Kjelsberg, Susanna Cotecchia, Jerzy Ostrowski et al. · Journal of Biological Chemistry · 1992 · 599 citations · Full text

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

Brian F. O’Dowd, Mark Hnatowich, John W. Regan et al. · Journal of Biological Chemistry · 1988 · 407 citations · Full text

Molecular Biology, Cellular Physiology, Molecular Pharmacology +18