Easily Accessible Mono‐ and Polytopic β‐Cyclodextrin Hosts by Click Chemistry

Abstract

Abstract A great variety of mono‐ and polytopic β‐cyclodextrin hosts have been easily synthesized by using the Cu I ‐catalyzed azide–alkyne cycloaddition reaction. Of particular interest for their multibinding properties, dimeric and trimeric CD compounds were obtained by “clicking” mono‐6‐azido‐β‐cyclodextrin derivatives with flexible or rigid dialkynyl spacers. The reaction is general, high‐yielding for some of the synthesized molecules (>80 %) and proceeds under mild conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)