Pharmacokinetic Analysis of Hypoxia ¹⁸F-Fluoromisonidazole Dynamic PET in Head and Neck Cancer

Abstract

There is a positive correlation of 0.86 between the average T/B and average hypoxia index K(i) of the region of interest. However, because of the statistical photon counting noise in PET and the amplification of noise in kinetic analysis, the direct correlation between the T/B and hypoxia of the individual pixel is not obvious. For a tumor region of interest, there is a slight negative correlation between k(1) and K(i), moderate positive correlation between beta and K(i), but no correlation between beta and k(1).