Concepedia

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

Sonia Martínez‐Revelles, María Soledad Avendaño, Ana B. García‐Redondo, Yolanda Álvarez, Andrea Aguado, José Vicente Pérez-Girón, Laura García-Redondo, Vanesa Esteban, Juan Miguel Redondo, María J. Alonso,

Antioxidants and Redox Signaling · 2012 · 155 citations · 30 references

DOI

Abstract

The excess of ROS from NAD(P)H Oxidase and/or mitochondria and the increased vascular COX-2/TP receptor axis act in concert to induce vascular dysfunction and hypertension.

References

30

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Anna Dikalova, Alfiya Bikineyeva, Klaudia Budzyn et al. · Circulation Research · 2010 · 719 citations · Full text

Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide.

Ying Xia, Gabriela García, Daniel Hwang et al. · Journal of Clinical Investigation · 1995 · 485 citations · Full text

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Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells

Shinsuke Kiritoshi, Takeshi Nishikawa, Kazuhiro Sonoda et al. · Diabetes · 2003 · 343 citations · Full text

Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice

Agostino Virdis, Mário Fritsch Neves, Farhad Amiri et al. · Journal of Hypertension · 2004 · 243 citations

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

Davide Gianni, Nicolas Taulet, Hui Zhang et al. · ACS Chemical Biology · 2010 · 185 citations

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