Identification and characterization of the tuberous sclerosis gene on chromosome 16

Cell

ChromatinCytogeneticsGenetic DisorderGeneticsPathology +8

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

Raymond S. Yeung, G H Xiao, Fuzi Jin, +3

Proceedings of the National Academy of Sciences

UrologySomatic VariantGenitourinary CancerKidney ResearchGenetic Predisposition +12

A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer

Toshiyuki Kobayashi, Youko Hirayama, Etsuko Kobayashi, +2

Nature Genetics

Developmental BiologyOncogenic AgentMedicineEker Rat ModelPathology +6

Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.

Okio Hino, Andres J. Klein–Szanto, Jerome J. Freed, +6

Proceedings of the National Academy of Sciences

Eker Rat ModelRenal PathologyPathologyTumor BiologyCarcinoma +14

A Dominant Gene for Renal Adenomas in the Rat

Reidar Eker, J. Mossige

Nature

UrologyRenal FunctionDominant GeneMedicineRenal Pathology +4

Hereditary Renal Cell Carcinoma in the Eker Rat: A Rodent Familial Cancer Syndrome

Jeffrey I. Everitt, Thomas L. Goldsworthy, Douglas C. Wolf, +1

The Journal of Urology

UrologyTumoral PathologyGenitourinary CancerKidney ResearchRenal Pathology +11

Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure.

Yoshiaki Kubo, Fritz Klimek, Yasushi Kikuchi, +2

PubMed

Eker Rat ModelRenal PathologyPathologyEker RatsTumor Biology +17

SRY protein enhances transcription of Fos-related antigen 1 promoter constructs.

Donna Cohén, Andrew Sinclair, Jill McGovern

Proceedings of the National Academy of Sciences

SpermatogenesisTestis DeterminationMolecular RegulationGeneticsMolecular Genetics +19

Relationship between serum and histochemical markers for hepatitis B virus and rate of viral integration in hepatocellular carcinomas in Japan

Okio Hino, Tomoyuki Kitagawa, Haruo Sugano

International Journal of Cancer

The Predisposing Gene of the Eker Rat Inherited Cancer Syndrome Is Tightly Linked to the Tuberous Sclerosis (TSC2) Gene

Ohio Hino, Toshiyuki Kobayashi, Haruo Tsuchiya, +4

Biochemical and Biophysical Research Communications

Genetic DisorderPathologyPredisposing GeneTumor SuppressorDisease Gene Identification +5