Scleroderma-Like Lesions in Multiple Myeloma

Abstract

A case of IgG-χ multiple myeloma is reported with coexistent scleroderma-like skin lesions. Histological, histochemical, electron microscopic and immunohistochemical studies failed to reveal amyloid in the skin, muscles, intestine and kidney. No macroglossia or other features characteristic of systemic amyloi dosis have been revealed. Attention is called to disturbances of tryptophan metabolism (increased level of indoles) which may play some role in the pathomechanism of the indurations. The possible transformation of paraprotein to histochemically-detectable amyloid is discussed.