Chemical Communications · 2015 · 61 citations · 29 references
Life SciencesBiophysicsCell BiologyCell BiophysicsMitochondrial BiologyMolecular ImagingFluorescence ImagingFluorescence MicroscopyMitochondrial FunctionMitochondrial PhysiologyMolecular Probe DevelopmentReactive Oxygen SpeciesCellular Fluorescence ImagingFluorescence Imaging ProbesFluorescent Probe DesignFluorescent ProbesFluorescent Reactive Oxygen Species ProbesLive-cell Fluorescence ImagingLive-cell Imaging ProbesReactive Oxygen Species Measurement
An amine-reactive fluorogenic molecule specifically turned on by superoxide radicals (O2˙(-)) was synthesized and coupled to a mitochondrial (MT) targeting peptide. The obtained probe showed superior uptake and MT targeting capabilities; and successfully detected the change in O2˙(-) levels in cells treated with chemical stimuli or single-walled carbon nanotubes.
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Superoxide dismutase as a target for the selective killing of cancer cells
Peng Huang, Feng Li, Eli Oldham et al. · Nature · 2000 · 841 citations