Proliferation and apoptosis of human CD8+CD28+ and CD8+CD28− lymphocytes during aging

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

Jason M. Brenchley, Nitin J. Karandikar, Michael R. Betts et al. · Blood · 2003 · 1K citations

Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

Francesco Fagnoni, Rosanna Vescovini, Giovanni Passeri et al. · Blood · 2000 · 515 citations

CD28- T lymphocytes. Antigenic and functional properties

Miyuki Azuma, Joseph H. Phillips, Lewis L. Lanier · The Journal of Immunology · 1993 · 390 citations

Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence

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Possible Cause, Autoimmune Disease, T-regulatory Cell +9

<b>Expansion of cytotoxic CD8⁺ CD28⁻ T cells in healthy ageing people, including centenarians</b>

F F Fagnoni, Rosanna Vescovini, Marco Mazzola et al. · Immunology · 1996 · 357 citations