Concepedia

Water-soluble third generation antitumor platinum complexes, [2,2-bis(aminomethyl)-1,3-propanediol-N,N']-[1,1-cyclobutanedicarboxylato(2-)-O,O']platinum(II) and [1,1-cyclobutanedicarboxylato(2-)-O,O'][tetrahydro-4H-pyran-4,4-dimethanamine-N,N']platinum(II)

Panayota Bitha, Suzanne G. Carvajal, Ronald V. Citarella, Ralph G. Child, Eugenia F. Delos Santos, T. S. DUNNE, Fredrick E. Durr, Joseph J. Hlavka, Stanley A. Lang

Journal of Medicinal Chemistry · 1989 · 39 citations · 0 references

DOI

Concepts

Inorganic ChemistryMedicinal ChemistryAntitumor ActivityNatural SciencesMedicineCoordination ComplexGreatest PromiseMolecular ComplexChemistryPharmacologyTetrahydro-4h-pyran-4,4- Dimethanamine-nInorganic SynthesisDrug DiscoveryInorganic Compound

Abstract

The synthesis, stability, and antitumor activity of a series of water-soluble third generation platinum(II) complexes have been described. Among these complexes, [2,2-bis(aminomethyl)-1,3- propanediol-N,N'] [1,1-cyclobutanedicarboxylato(2-)-O,O']platinum(II) and [1,1-cyclobutanedicarboxylate(2-)-O,O'](tetrahydro-4H-pyran-4,4- dimethanamine-N,N'-)platinum(II) have shown the greatest promise for further investigation and are currently under clinical evaluation.